Rules for the use of commas.

Rule 1. Use commas to separate words and word groups in a simple series of three or more items.

Rule 2. Use a comma to separate two adjectives when the adjectives are interchangeable.

Example: He is a strong, healthy man.
We could also say healthy, strong man.

Rule 3. Use a comma after certain words that introduce a sentence, such as well, yes, why, hello, hey, etc.

Examples:
Why, I can't believe this!
No, you can't have a dollar

Rule 4. Use commas to set off expressions that interrupt the sentence flow (nevertheless, after all, by the way, on the other hand, however, etc.).

Example: I am, by the way, very nervous about this.

Rule 5. Use commas to set off the name, nickname, term of endearment, or title of a person directly addressed.

Examples:
Will you, Aisha, do that assignment for me?
Yes, old friend, I will.
Good day, Captain.

So,here you have it guys 5 simple rules for the use of commas.